Biological membranes mediate several biological processes that are directly associated with their physical properties but sometimes difficult to evaluate.Supported lipid bilayers (SLBs) are model systems widely used to characterize the structure of biological membranes.Cholesterol (Chol) plays an essential role in the modulation of membrane physica
Human Paraoxonase 1 as a Pharmacologic Agent: Limitations and Perspectives
Human PON1 (h-PON1) is a multifaceted enzyme and can hydrolyze (and inactivate) a wide range of substrates.The enzyme shows anti-inflammatory, antioxidative, antiatherogenic, ant-diabetic, antimicrobial, and organophosphate (OP)-detoxifying properties.However, there are certain limitations regarding large-scale production and use of h-PON1 as Helme
Progesterone reduces erectile dysfunction in sleep-deprived spontaneously hypertensive rats
Abstract Background Paradoxical sleep deprivation (PSD) associated with copyright has been shown to enhance genital reflexes (penile erection-PE and ejaculation-EJ) in Wistar rats.Since hypertension predisposes males to erectile dysfunction, the aim of the present study was to investigate the effects of PSD on genital reflexes in the spontaneously